The series' protagonist and title character is Dr. The season was officially released on DVD as two-disc Region 1 box set under the title of Grey's Anatomy: Season One on February 14, 2006, by Buena Vista Home Entertainment. Although no clip shows have been produced for this season, the events that occur are recapped in ' Straight to Heart', a clip-show which aired one week before the winter holiday hiatus of the second season ended.

The season initially served as a mid-season replacement for the legal drama Boston Legal, airing in the Sunday night time slot at 10:00, after Desperate Housewives. Season one had nine series regulars, three of whom have been part of the main cast ever since. The first season introduces the main character, Meredith Grey, as she enrolls in Seattle Grace Hospital's internship program and faces unexpected challenges and surprises. The first season of the American television medical drama Grey's Anatomy, began airing in the United States on the American Broadcasting Company (ABC) on March 27, 2005, and concluded on May 22, 2005.

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